Description
SR3335, also known as ML 176, is a RORα selective inverse agonist. SR3335 directly binds to RORα, but not other RORs, and functions as a selective partial inverse agonist of RORα in cell-based assays. Furthermore, SR3335 suppresses the expression of endogenous RORα target genes in HepG2 involved in hepatic gluconeogenesis including glucose-6-phosphatase and phosphoenolpyruvate carboxykinase. SR3335 can be utilized as a chemical tool to probe the function of this receptor both in vitro and in vivo. SR3335 may hold utility for suppression of elevated hepatic glucose production in type 2 diabetics.
Product information
CAS Number: 293753-05-6
Molecular Weight: 405.34
Formula: C13H9F6NO3S2
Chemical Name: N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]thiophene-2-sulfonamide
Smiles: OC(C1C=CC(=CC=1)NS(=O)(=O)C1=CC=CS1)(C(F)(F)F)C(F)(F)F
InChiKey: LZWUNZRMANFRAO-UHFFFAOYSA-N
InChi: InChI=1S/C13H9F6NO3S2/c14-12(15,16)11(21,13(17,18)19)8-3-5-9(6-4-8)20-25(22,23)10-2-1-7-24-10/h1-7,20-21H
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥360 days if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
Products are for research use only. Not for human use.
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