Description
10, 11-Dehydrocurvularin is a prevalent fungal phytotoxin and an antibiotic. 10, 11-Dehydrocurvularin is a strong activator of the heat shock response. 10, 11-Dehydrocurvularin inhibits TGF-β signalling pathway. Anti-tumorous activity.
Product information
CAS Number: 21178-57-4
Molecular Weight: 290.31
Formula: C16H18O5
Chemical Name: (4S)-11, 13-dihydroxy-4-methyl-2, 4, 5, 6, 7, 10-hexahydro-1H-3-benzoxacyclododecine-2, 10-dione
Smiles: C[C@H]1CCCC=CC(=O)C2=C(CC(=O)O1)C=C(O)C=C2O |t:5|
InChiKey: AVIRMQMUBGNCKS-OAQKJQOQSA-N
InChi: InChI=1S/C16H18O5/c1-10-5-3-2-4-6-13(18)16-11(8-15(20)21-10)7-12(17)9-14(16)19/h4,6-7,9-10,17,19H,2-3,5,8H2,1H3/b6-4-/t10-/m0/s1
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: Soluble in DMSO
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
References:
- Xu Y, et al. Characterization of the biosynthetic genes for 10,11-dehydrocurvularin, a heat shock response-modulating anticancer fungal polyketide from Aspergillus terreus. Appl Environ Microbiol. 2013 Mar;79(6):2038-47.
- Cochrane RV, et al. Comparison of 10,11-Dehydrocurvularin Polyketide Synthases from Alternaria cinerariae and Aspergillus terreus Highlights Key Structural Motifs. Chembiochem. 2015 Nov;16(17):2479-83.
Products are for research use only. Not for human use.
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