Ganoderic acid A

Ganoderic acid A can inhibit of the JAK-STAT3 signaling pathway, also inhibit proliferation, viability, ROS.

Product information

CAS Number: 81907-62-2

Molecular Weight: 516.67

Formula: C30H44O7

Chemical Name: (2R, 6R)-6-[(1R, 3S, 3aR, 4S, 5aR, 9aS, 11aR)-3, 4-dihydroxy-3a, 6, 6, 9a, 11a-pentamethyl-7, 10-dioxo-1H, 2H, 3H, 3aH, 4H, 5H, 5aH, 6H, 7H, 8H, 9H, 9aH, 10H, 11H, 11aH-cyclopenta[a]phenanthren-1-yl]-2-methyl-4-oxoheptanoic acid

Smiles: CC1(C)[C@@H]2C[C@H](O)C3=C(C(=O)C[C@]4(C)[C@H](C[C@H](O)[C@]43C)[C@H](C)CC(=O)C[C@@H](C)C(O)=O)[C@@]2(C)CCC1=O

InChiKey: DYOKDAQBNHPJFD-JNTBEZBXSA-N

InChi: InChI=1S/C30H44O7/c1-15(10-17(31)11-16(2)26(36)37)18-12-23(35)30(7)25-19(32)13-21-27(3,4)22(34)8-9-28(21,5)24(25)20(33)14-29(18,30)6/h15-16,18-19,21,23,32,35H,8-14H2,1-7H3,(H,36,37)/t15-,16-,18-,19+,21+,23+,28+,29-,30+/m1/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : ≥ 29 mg/mL (56.13 mM)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

A lower doses of Ganoderic acid A enhance HLA class II-mediated antigen presentation and CD4+ T cell recognition of lymphoma. Ganoderic acid A promots cisplatin-induced cell death by enhancing the sensitivity of HepG2 cells to cisplatin mainly via the signal transducer and activator of transcription 3 suppression. Ganoderic acid Ainhibits proliferation, viability, ROS, DPPH, and analyzed the expression of SOD1, SOD2, and SOD3 by Real time PCR in a PC-3 cell in a dose-dependent manner. Ganoderic acid A effectively inhibites the proliferation of human osteosarcoma HOS and MG-63 cells in a dose-dependent manner, and induced obvious cell apoptosis in both cells.

In Vivo:

Ganoderic acid A treatment significantly prolonged survival of EL4 challenged mice and decreased tumor metastasis to the liver.

References:

1. Radwan FF et al. Reduction of myeloid-derived suppressor cells and lymphoma growth by a natural triterpenoid. J Cell Biochem. 2015 Jan;116(1):102-14.
2. Yao X et al. Inhibition of the JAK-STAT3 signaling pathway by ganoderic acid A enhances chemosensitivity of HepG2 cells to cisplatin. Planta Med. 2012 Nov;78(16):1740-8.
3. Gill BS et al. Evaluating anti-oxidant potential of ganoderic acid A in STAT 3 pathway in prostate cancer. Mol Biol Rep. 2016 Sep 17.

Products are for research use only. Not for human use.