Talampanel


Catalog No. Size PriceQuantity
M12553-2 2mg solid $105
M12553-10 10mg solid $315

Description

Talampanel (LY300164) is an orally and selective α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) receptor antagonis with anti-seizure activity. Talampanel (IVAX) has neuroprotective effects in rodent stroke models. Talampanel attenuates caspase-3 dependent apoptosis in mouse brain.

Product information

CAS Number: 161832-65-1

Molecular Weight: 337.37

Formula: C19H19N3O3

Synonym:

GYKI-53773

LY-300164

Chemical Name: 1-[(13R)-10-(4-aminophenyl)-13-methyl-4, 6-dioxa-11, 12-diazatricyclo[7.5.0.0, ]tetradeca-1(9), 2, 7, 10-tetraen-12-yl]ethan-1-one

Smiles: CC(=O)N1N=C(C2=CC3OCOC=3C=C2C[C@H]1C)C1C=CC(N)=CC=1

InChiKey: JACAAXNEHGBPOQ-LLVKDONJSA-N

InChi: InChI=1S/C19H19N3O3/c1-11-7-14-8-17-18(25-10-24-17)9-16(14)19(21-22(11)12(2)23)13-3-5-15(20)6-4-13/h3-6,8-9,11H,7,10,20H2,1-2H3/t11-/m1/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : ≥ 100 mg/mL (296.41 mM)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vivo:

Talampanel (orally administration; 5 mg/kg; once a day; 2 weeks) reduces motoneuronal calcium in a mouse model of ALS, but its efficacy declines as the disease progresses.

References:

  1. Paizs M, et al. Talampanel reduces the level of motoneuronal calcium in transgenic mutant SOD1 mice only if applied presymptomatically. Amyotroph Lateral Scler. 2011 Sep;12(5):340-4.
  2. Denes L, et al. Talampanel a non-competitive AMPA-antagonist attenuates caspase-3 dependent apoptosis in mouse brain after transient focal cerebral ischemia. Brain Res Bull. 2006 Jul 31;70(3):260-2. Epub 2006 Mar 31.

Products are for research use only. Not for human use.

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