Furazolidone


Catalog No. Size PriceQuantity
M12555-2 2mg solid $80
M12555-10 10mg solid $240

Description

Furazolidone is a nitrofuran derivative with antiprotozoal and antibacterial activity, inhibits AML1-ETO transformed cells with IC50 value of 12.7 μM. Target: Antibacterial Furazolidone is a novel therapeutic strategy in AML patients. Furazolidone can Inhibit the bone-marrow transformation mediated by a series of leukemia fusion proteins. Furazolidone significantly inhibits proliferation of AML cell lines. Furazolidone induces apoptosis of the AML leukemic cells treatment with Furazolidone induces differentiation of AML cell lines.

Product information

CAS Number: 67-45-8

Molecular Weight: 225.16

Formula: C8H7N3O5

Chemical Name: 3-[(E)-[(5-nitrofuran-2-yl)methylidene]amino]-1, 3-oxazolidin-2-one

Smiles: [O-][N+](=O)C1=CC=C(/C=N/N2CCOC2=O)O1

InChiKey: PLHJDBGFXBMTGZ-WEVVVXLNSA-N

InChi: InChI=1S/C8H7N3O5/c12-8-10(3-4-15-8)9-5-6-1-2-7(16-6)11(13)14/h1-2,5H,3-4H2/b9-5+

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 10 mg/mL (44.41 mM; Need ultrasonic) H2O : < 0.1 mg/mL (insoluble)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

  1. Jiang X, et al. A novel application of furazolidone: anti-leukemic activity in acute myeloid leukemia. PLoS One. 2013 Aug 9;8(8):e72335.

Products are for research use only. Not for human use.

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