Description
PARP14 inhibitor H10, compound H 10, is a selective inhibitor against PARP14 (IC50=490 nM), over other PARPs (≈24 fold over PARP1). PARP14 inhibitor H10 induces caspase-3/7-mediated cell apoptosis.
Product information
CAS Number: 2084811-68-5
Molecular Weight: 557.58
Formula: C24H27N7O7S
Chemical Name: 3-({2-[4-(2-{3-[(3-carbamoylphenyl)carbamoyl]propanamido}ethyl)-1H-1, 2, 3-triazol-1-yl]ethyl}sulfamoyl)benzoic acid
Smiles: NC(=O)C1=CC(=CC=C1)NC(=O)CCC(=O)NCCC1=CN(CCNS(=O)(=O)C2=CC(=CC=C2)C(O)=O)N=N1
InChiKey: MUOMSHSMJCWQFH-UHFFFAOYSA-N
InChi: InChI=1S/C24H27N7O7S/c25-23(34)16-3-1-5-18(13-16)28-22(33)8-7-21(32)26-10-9-19-15-31(30-29-19)12-11-27-39(37,38)20-6-2-4-17(14-20)24(35)36/h1-6,13-15,27H,7-12H2,(H2,25,34)(H,26,32)(H,28,33)(H,35,36)
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO : 62.5 mg/mL (112.09 mM; Need ultrasonic)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥360 days if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
References:
- Peng B, et al. Small Molecule Microarray Based Discovery of PARP14 Inhibitors. Angew Chem Int Ed Engl. 2017 Jan 2;56(1):248-253.
Products are for research use only. Not for human use.
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