Description
Ivachtin (Caspase-3 Inhibitor VII; compound 7a) is a nonpeptide, noncompetitive and reversibl caspase-3 inhibitor with an IC50 of 23 nM. Ivachtin has modest selectivity for the remaining caspases.
Product information
CAS Number: 745046-84-8
Molecular Weight: 447.46
Formula: C20H21N3O7S
Synonym:
Caspase-3 Inhibitor VII
Chemical Name: 2-[4-methyl-8-(morpholine-4-sulfonyl)-1, 3-dioxo-1H, 2H, 3H-pyrrolo[3, 4-c]quinolin-2-yl]ethyl acetate
Smiles: CC(=O)OCCN1C(=O)C2=C(C1=O)C(C)=NC1=CC=C(C=C21)S(=O)(=O)N1CCOCC1
InChiKey: MWXJJTMEUGWKKY-UHFFFAOYSA-N
InChi: InChI=1S/C20H21N3O7S/c1-12-17-18(20(26)23(19(17)25)7-10-30-13(2)24)15-11-14(3-4-16(15)21-12)31(27,28)22-5-8-29-9-6-22/h3-4,11H,5-10H2,1-2H3
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: Soluble in DMSO
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥360 days if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
Ivachtin (Caspase-3 Inhibitor VII; compound 7a; 10, 100 μM) has protective effect in a model of staurosporininduced apoptosis in human Jurkat T cells.
References:
- Kravchenko DV, et al. Synthesis and structure-activity relationship of 4-substituted 2-(2-acetyloxyethyl)-8-(morpholine-4-sulfonyl)pyrrolo[3,4-c]quinoline-1,3-diones as potent caspase-3 inhibitors. J Med Chem. 2005 Jun 2;48(11):3680-3.
Products are for research use only. Not for human use.
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