Senkyunolide I


Catalog No. Size PriceQuantity
M12716-2 2mg solid $725
M12716-10 10mg solid $2,900

Description

Senkyunolide I, isolated from Ligusticum chuanxiong Hort, is an anti-migraine compound. Senkyunolide I protects rat brain against focal cerebral ischemia-reperfusion injury by up-regulating p-Erk1/2, Nrf2/HO-1 and inhibiting caspase 3.

Product information

CAS Number: 94596-28-8

Molecular Weight: 224.25

Formula: C12H16O4

Chemical Name: (3Z, 6S, 7S)-3-butylidene-6, 7-dihydroxy-1, 3, 4, 5, 6, 7-hexahydro-2-benzofuran-1-one

Smiles: CCC/C=C1\OC(=O)C2[C@H](O)[C@@H](O)CCC=2\1

InChiKey: DQNGMIQSXNGHOA-JXQVETIVSA-N

InChi: InChI=1S/C12H16O4/c1-2-3-4-9-7-5-6-8(13)11(14)10(7)12(15)16-9/h4,8,11,13-14H,2-3,5-6H2,1H3/b9-4-/t8-,11+/m0/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 100 mg/mL (445.93 mM; Need ultrasonic)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

  1. Wang YH, et al. Effect and mechanism of senkyunolide I as an anti-migraine compound from Ligusticum chuanxiong. J Pharm Pharmacol. 2011 Feb;63(2):261-6.
  2. Hu Y, et al. Senkyunolide I protects rat brain against focal cerebral ischemia-reperfusion injury by up-regulating p-Erk1/2, Nrf2/HO-1 and inhibiting caspase 3. Brain Res. 2015 Apr 24;1605:39-48.

Products are for research use only. Not for human use.

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