Description
(3-Carboxypropyl)trimethylammonium chloride (γ-Butyrobetaine, γBB hydrochloride) is an intermediary metabolite by gut microbes from dietary L-carnitine in mice.
Product information
CAS Number: 6249-56-5
Molecular Weight: 181.66
Formula: C7H16ClNO2
Synonym:
γ-Butyrobetaine hydrochloride
Chemical Name: (3-carboxypropyl)trimethylazanium chloride
Smiles: [Cl-].C[N+](C)(C)CCCC(O)=O
InChiKey: GNRKTORAJTTYIW-UHFFFAOYSA-N
InChi: InChI=1S/C7H15NO2.ClH/c1-8(2,3)6-4-5-7(9)10;/h4-6H2,1-3H3;1H
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO : 30 mg/mL (165.14 mM; Need ultrasonic)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
(3-Carboxypropyl)trimethylammonium chloride is produced as an intermediary metabolite by gut microbes of L-Carnitine to TMAO. (3-Carboxypropyl)trimethylammonium chloride is implicated in arteriosclerosis and long-term cardiovascular death.
References:
- Koeth RA, et al. γ-Butyrobetaine is a proatherogenic intermediate in gut microbial metabolism of L-carnitine to TMAO. Cell Metab. 2014 Nov 4;20(5):799-812.
- Susumu Ogawa, et al. The Dynamics of Carnitine, γ-butyrobetaine and Trimethylamine N-oxide in Diabetics and the Effects of Changes in Renal Function. Ogawa et al., J Nephrol Ren Dis 2017, 1:2
Products are for research use only. Not for human use.
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