Sodium Houttuyfonate

Sodium Houttuyfonate is a natural compound extracted from Houttuynia cordata, with anti-inflammatory and anti-fibrotic effects. Sodium Houttuyfonate ameliorates LPS induced mastitis by inhibiting the NF κB pathway.

Product information

CAS Number: 83766-73-8

Molecular Weight: 302.36

Formula: C12H23NaO5S

Chemical Name: sodium 1-hydroxy-3-oxododecane-1-sulfonate

Smiles: [Na+].CCCCCCCCCC(=O)CC(O)S([O-])(=O)=O

InChiKey: HPPWMWCITPGPKK-UHFFFAOYSA-M

InChi: InChI=1S/C12H24O5S.Na/c1-2-3-4-5-6-7-8-9-11(13)10-12(14)18(15,16)17;/h12,14H,2-10H2,1H3,(H,15,16,17);/q;+1/p-1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 5 mg/mL (16.54 mM; ultrasonic and warming and heat to 60°C).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

Sodium houttuyfonate (25-100 mM) decreases apoptosis of MLE-15 cells induced by CS experiment and inhibits JNK pathway.

In Vivo:

Sodium Houttuyfonate (10-40 mg/kg; p.o. for 28 d) reduces lung injury, apoptosis in lung tissues, and the wet/dry (W/D) ratio in ventilator-induced lung injury (VILI) mice. Sodium Houttuyfonate (40 mg/kg; p.o. for 28 d) reduces ROS level and inhibits JNK pathway in VILI mice. Sodium Houttuyfonate (25-100 mg/kg; p.o. once daily for 28 d) ameliorates spatial learning and memory deficiency in Aβ1-42-induced Alzheimer's disease mice.

References:

1. Liu Y, et, al. Effect and Mechanism Study of Sodium Houttuyfonate on Ventilator-Induced Lung Injury by Inhibiting ROS and Inflammation. Yonsei Med J. 2021 Jun;62(6):545-554.
2. Liu X, et, al. Sodium houttuyfonate: A review of its antimicrobial, anti-inflammatory and cardiovascular protective effects. Eur J Pharmacol. 2021 Jul 5;902:174110.
3. Zhao Y, et, al. Sodium Houttuyfonate Ameliorates β-amyloid 1-42-Induced Memory Impairment and Neuroinflammation through Inhibiting the NLRP3/GSDMD Pathway in Alzheimer's Disease. Mediators Inflamm. 2021 May 31;2021:8817698.
4. Ma K, et, al. Sodium houttuyfonate attenuates dextran sulfate sodium associated colitis precolonized with Candida albicans through inducing β-glucan exposure. J Leukoc Biol. 2021 Mar 8.

Products are for research use only. Not for human use.