Description
m-PEG3-NHS ester is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
Product information
CAS Number: 876746-59-7
Molecular Weight: 289.28
Formula: C12H19NO7
Chemical Name: 2,5-dioxopyrrolidin-1-yl 3-[2-(2-methoxyethoxy)ethoxy]propanoate
Smiles: COCCOCCOCCC(=O)ON1C(=O)CCC1=O
InChiKey: TYCOYHPJUNAABD-UHFFFAOYSA-N
InChi: InChI=1S/C12H19NO7/c1-17-6-7-19-9-8-18-5-4-12(16)20-13-10(14)2-3-11(13)15/h2-9H2,1H3
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: Soluble in DMSO
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
References:
- Lepage ML, et al. Design, synthesis and photochemical properties of the first examples of iminosugar clustersbased on fluorescent cores. Beilstein J Org Chem. 2015 May 6;11:659-67.
Products are for research use only. Not for human use.
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