Description
m-PEG10-azide a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
Product information
CAS Number: 2112738-12-0
Molecular Weight: 497.58
Formula: C21H43N3O10
Chemical Name: 31-azido-2,5,8,11,14,17,20,23,26,29-decaoxahentriacontane
Smiles: COCCOCCOCCOCCOCCOCCOCCOCCOCCOCCN=[N+]=[N-]
InChiKey: JIJUYQJOYRMNAR-UHFFFAOYSA-N
InChi: InChI=1S/C21H43N3O10/c1-25-4-5-27-8-9-29-12-13-31-16-17-33-20-21-34-19-18-32-15-14-30-11-10-28-7-6-26-3-2-23-24-22/h2-21H2,1H3
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: Soluble in DMSO
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
References:
- Lepage ML, et al. Design, synthesis and photochemical properties of the first examples of iminosugar clustersbased on fluorescent cores. Beilstein J Org Chem. 2015 May 6;11:659-67.
Products are for research use only. Not for human use.
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