m-PEG5-sulfonic acid


Catalog No. Size PriceQuantity
M13392-2 Contact sales@xcessbio.com for quotation $100
M13392-10 Contact sales@xcessbio.com for quotation $100

Description

m-PEG5-sulfonic acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Product information

CAS Number: 1807505-35-6

Molecular Weight: 316.37

Formula: C11H24O8S

Chemical Name: 2,5,8,11,14-pentaoxahexadecane-16-sulfonic acid

Smiles: COCCOCCOCCOCCOCCS(O)(=O)=O

InChiKey: ZWHMRCZZWNHUNQ-UHFFFAOYSA-N

InChi: InChI=1S/C11H24O8S/c1-15-2-3-16-4-5-17-6-7-18-8-9-19-10-11-20(12,13)14/h2-11H2,1H3,(H,12,13,14)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

References:

  1. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Products are for research use only. Not for human use.

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