m-PEG8-Ms


Catalog No. Size PriceQuantity
M13398-2 Contact sales@xcessbio.com for quotation $100
M13398-10 Contact sales@xcessbio.com for quotation $100

Description

m-PEG8-Ms is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. m-PEG8-Ms is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

Product information

CAS Number: 1059588-19-0

Molecular Weight: 462.55

Formula: C18H38O11S

Chemical Name: 2,5,8,11,14,17,20,23-octaoxapentacosan-25-yl methanesulfonate

Smiles: COCCOCCOCCOCCOCCOCCOCCOCCOS(C)(=O)=O

InChiKey: AQFJPOUIRSKMIV-UHFFFAOYSA-N

InChi: InChI=1S/C18H38O11S/c1-21-3-4-22-5-6-23-7-8-24-9-10-25-11-12-26-13-14-27-15-16-28-17-18-29-30(2,19)20/h3-18H2,1-2H3

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

References:

  1. Sanxing Sun, et al. Triazolotriazine derivatives as a2a receptor antagonists. WO2020002969A1.

Products are for research use only. Not for human use.

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