m-PEG5-nitrile


Catalog No. Size PriceQuantity
M13400-2 Contact sales@xcessbio.com for quotation $100
M13400-10 Contact sales@xcessbio.com for quotation $100

Description

m-PEG5-nitrile is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.

Product information

CAS Number: 81836-41-1

Molecular Weight: 261.31

Formula: C12H23NO5

Chemical Name: 2,5,8,11,14-pentaoxaheptadecane-17-nitrile

Smiles: COCCOCCOCCOCCOCCC#N

InChiKey: SZUWOHFZIMGHKQ-UHFFFAOYSA-N

InChi: InChI=1S/C12H23NO5/c1-14-5-6-16-9-10-18-12-11-17-8-7-15-4-2-3-13/h2,4-12H2,1H3

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

References:

  1. Saifer MG, et al. Selectivity of binding of PEGs and PEG-like oligomers to anti-PEG antibodies induced by methoxyPEG-proteins. Mol Immunol. 2014 Feb;57(2):236-46.

Products are for research use only. Not for human use.

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