IKKγ NBD Inhibitory Peptide - CAS# 372146-18-4

IKKγ NBD Inhibitory Peptide is a NEMO-binding domain peptide (NBD peptide) corresponding to the NEMO amino-terminal alpha-helical region, which is shown to block TNF-alpha-induced NF-kB activation.

Product information

CAS Number: 372146-18-4

Molecular Weight: 3693.24

Formula: C170H259N49O42S

Chemical Name: IKKgamma NBD Inhibitory Peptide

Smiles: CSCC[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC1C=CC=CC=1)NC(=O)[C@H](CC1=CNC2=CC=CC=C12)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](N)CC(O)=O)[C@@H](C)CC)[C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CNC2=CC=CC=C12)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC1=CNC2=CC=CC=C12)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CNC2=CC=CC=C12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCC(O)=O)C(O)=O

InChiKey: MJLJQYXWQIGWNE-FHKTVDBHSA-N

InChi: InChI=1S/C170H259N49O42S/c1-13-88(7)136(217-151(244)115(55-59-130(177)224)200-143(236)111(51-34-67-186-168(180)181)194-141(234)102(175)78-134(229)230)163(256)204-110(50-29-33-66-174)149(242)216-137(89(8)14-2)164(257)214-125(77-97-84-192-106-46-25-21-42-101(97)106)158(251)208-121(73-93-37-16-15-17-38-93)155(248)201-114(54-58-129(176)223)147(240)212-126(79-132(179)226)160(253)199-113(53-36-69-188-170(184)185)144(237)197-112(52-35-68-187-169(182)183)145(238)203-117(62-70-262-12)148(241)195-108(48-27-31-64-172)146(239)209-122(74-94-81-189-103-43-22-18-39-98(94)103)156(249)198-107(47-26-30-63-171)142(235)196-109(49-28-32-65-173)150(243)218-138(91(10)221)165(258)193-90(9)140(233)206-119(71-86(3)4)154(247)213-127(80-135(231)232)161(254)210-124(76-96-83-191-105-45-24-20-41-100(96)105)159(252)215-128(85-220)162(255)211-123(75-95-82-190-104-44-23-19-40-99(95)104)157(250)207-120(72-87(5)6)153(246)202-116(56-60-131(178)225)152(245)219-139(92(11)222)166(259)205-118(167(260)261)57-61-133(227)228/h15-25,37-46,81-84,86-92,102,107-128,136-139,189-192,220-222H,13-14,26-36,47-80,85,171-175H2,1-12H3,(H2,176,223)(H2,177,224)(H2,178,225)(H2,179,226)(H,193,258)(H,194,234)(H,195,241)(H,196,235)(H,197,237)(H,198,249)(H,199,253)(H,200,236)(H,201,248)(H,202,246)(H,203,238)(H,204,256)(H,205,259)(H,206,233)(H,207,250)(H,208,251)(H,209,239)(H,210,254)(H,211,255)(H,212,240)(H,213,247)(H,214,257)(H,215,252)(H,216,242)(H,217,244)(H,218,243)(H,219,245)(H,227,228)(H,229,230)(H,231,232)(H,260,261)(H4,180,181,186)(H4,182,183,187)(H4,184,185,188)/t88-,89-,90-,91+,92+,102-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,136-,137-,138-,139-/m0/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

1. Zhao J, et al. Development of novel NEMO-binding domain mimetics for inhibiting IKK/NF-κB activation. PLoS Biol. 2018 Jun 11;16(6):e2004663.

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