Description
BRD7-IN-1 free base, a modified derivative of BI7273 (BRD7/9 inhibitor), binds to a VHL ligand via a linker to form a PROTAC VZ185 (VZ185 against BRD7/9 with DC50s of 4.5 and 1.8 nM, respectively).
Product information
CAS Number: 2305379-66-0
Molecular Weight: 394.47
Formula: C22H26N4O3
Chemical Name: 4-{3,5-dimethoxy-4-[(piperazin-1-yl)methyl]phenyl}-2-methyl-1,2-dihydro-2,7-naphthyridin-1-one
Smiles: CN1C=C(C2=CC(OC)=C(CN3CCNCC3)C(=C2)OC)C2=CC=NC=C2C1=O
InChiKey: NWXABBDHVJBGQH-UHFFFAOYSA-N
InChi: InChI=1S/C22H26N4O3/c1-25-13-18(16-4-5-24-12-17(16)22(25)27)15-10-20(28-2)19(21(11-15)29-3)14-26-8-6-23-7-9-26/h4-5,10-13,23H,6-9,14H2,1-3H3
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
Products are for research use only. Not for human use.
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