Description
Zaurategrast ethyl ester sulfate (CDP323 sulfate), the ethyl ester prodrug of CT7758, is a α4β1/α4β7 integrin antagonist used for the treatment of inflammatory and autoimmune disorders.
Product information
CAS Number: 1214261-78-5
Molecular Weight: 647.54
Formula: C28H31BrN4O7S
Synonym:
CDP323 sulfate
UCB1184197 sulfate
Chemical Name: ethyl (2S)-2-({2-bromo-3-oxospiro[3.5]non-1-en-1-yl}amino)-3-{4-[(2,7-naphthyridin-1-yl)amino]phenyl}propanoate; sulfuric acid
Smiles: CCOC(=O)[C@H](CC1C=CC(=CC=1)NC1=NC=CC2C=CN=CC=21)NC1=C(Br)C(=O)C21CCCCC2.OS(O)(=O)=O
InChiKey: YAMQWVIKICWIKQ-FTBISJDPSA-N
InChi: InChI=1S/C28H29BrN4O3.H2O4S/c1-2-36-27(35)22(33-24-23(29)25(34)28(24)12-4-3-5-13-28)16-18-6-8-20(9-7-18)32-26-21-17-30-14-10-19(21)11-15-31-26;1-5(2,3)4/h6-11,14-15,17,22,33H,2-5,12-13,16H2,1H3,(H,31,32);(H2,1,2,3,4)/t22-;/m0./s1
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
Zaurategrast ethyl ester sulfate (CDP323 sulfate), an ethyl ester prodrug of CT7758, shows some improvements in increasing mass transfer.
References:
- Chanteux H, et al. Cross-Species Differences in the Preclinical Pharmacokinetics of CT7758, an α4β1/α4β7 Integrin Antagonist. Drug Metab Dispos. 2015 Sep;43(9):1381-91.
- Davenport RJ, et al. Alpha4-integrin antagonism--an effective approach for the treatment of inflammatory diseases? Drug Discov Today. 2007 Jul;12(13-14):569-76.
Products are for research use only. Not for human use.
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