Description
β-Amyloid (1-9), an N-terminal fragment of beta amyloid, consists of amino acid residues 1 to 9. β-Amyloid (1-9) contains a B cell epitope, but it does not include T cell epitopes. Omission of residues 1 to 9 from the full-length Alzheimer'sβ-Amyloid peptide 1 to 40 does not prevent the peptide from forming amyloid fibrils or eliminate fibril polymorphism .
Product information
CAS Number: 147529-30-4
Molecular Weight: 1033.01
Formula: C42H60N14O17
Chemical Name: (5S, 8S, 11S, 14S, 17S, 20S, 26S)-11-((1H-imidazol-5-yl)methyl)-26-amino-17-benzyl-20-(2-carboxyethyl)-8-(carboxymethyl)-14-(3-(diaminomethyleneamino)propyl)-5-(hydroxymethyl)-23-methyl-4, 7, 10, 13, 16, 19, 22, 25-octaoxo-3, 6, 9, 12, 15, 18, 21, 24-octaazaoctacosane-1, 28-dioic acid
Smiles: CC(NC(=O)[C@@H](N)CC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC1C=CC=CC=1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC1=CN=CN1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(=O)NCC(O)=O
InChiKey: BRRKPUCEVBBGNV-ZDLFWEFWSA-N
InChi: InChI=1S/C42H60N14O17/c1-20(50-35(67)23(43)14-31(60)61)34(66)51-25(9-10-30(58)59)38(70)53-26(12-21-6-3-2-4-7-21)39(71)52-24(8-5-11-47-42(44)45)37(69)54-27(13-22-16-46-19-49-22)40(72)55-28(15-32(62)63)41(73)56-29(18-57)36(68)48-17-33(64)65/h2-4,6-7,16,19-20,23-29,57H,5,8-15,17-18,43H2,1H3,(H,46,49)(H,48,68)(H,50,67)(H,51,66)(H,52,71)(H,53,70)(H,54,69)(H,55,72)(H,56,73)(H,58,59)(H,60,61)(H,62,63)(H,64,65)(H4,44,45,47)/t20?,23-,24-,25-,26-,27-,28-,29-/m0/s1
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
References:
- Zamora E, et al. Papillomavirus-like particles are an effective platform for amyloid-beta immunization in rabbitsand transgenic mice. J Immunol. 2006 Aug 15;177(4):2662-2670.
- Paravastu AK, et al. Polymorphic fibril formation by residues 10-40 of the Alzheimer's beta-amyloid peptide. Biophys J. 2006 Jun 15;90(12):4618-29.
Products are for research use only. Not for human use.
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