Br-PEG3-CH2COOH


Catalog No. Size PriceQuantity
M13865-2 Contact sales@xcessbio.com for quotation $100

Description

Br-PEG3-CH2COOH (compound 28) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.

Product information

CAS Number: 1346502-15-5

Molecular Weight: 271.11

Formula: C8H15BrO5

Chemical Name: 2-{2-[2-(2-bromoethoxy)ethoxy]ethoxy}acetic acid

Smiles: OC(=O)COCCOCCOCCBr

InChiKey: MNTZZZWRXHWCSC-UHFFFAOYSA-N

InChi: InChI=1S/C8H15BrO5/c9-1-2-12-3-4-13-5-6-14-7-8(10)11/h1-7H2,(H,10,11)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

References:

  1. Zha Z, et al. Multidentate (18)F-polypegylated styrylpyridines as imaging agents for Aβ plaques in cerebral amyloid angiopathy (CAA). J Med Chem. 2011 Dec 8;54(23):8085-98.

Products are for research use only. Not for human use.

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