Iberdomide


Catalog No. Size PriceQuantity
M13917-2 2 mg solid $65
M13917-10 10 mg solid $150
M13917-C Contact sales@xcessbio.com for quotation $100

Description

Iberdomide (CC-220) is a cereblon (CRBN) modulator with an IC50 value of 60 nM.

Product information

CAS Number: 1323403-33-3

Molecular Weight: 449.50

Formula: C25H27N3O5

Chemical Name: (3S)-3-[4-({4-[(morpholin-4-yl)methyl]phenyl}methoxy)-1-oxo-2,3-dihydro-1H-isoindol-2-yl]piperidine-2,6-dione

Smiles: O=C1NC(=O)CC[C@@H]1N1CC2C(=CC=CC=2C1=O)OCC1C=CC(CN2CCOCC2)=CC=1

InChiKey: IXZOHGPZAQLIBH-NRFANRHFSA-N

InChi: InChI=1S/C25H27N3O5/c29-23-9-8-21(24(30)26-23)28-15-20-19(25(28)31)2-1-3-22(20)33-16-18-6-4-17(5-7-18)14-27-10-12-32-13-11-27/h1-7,21H,8-16H2,(H,26,29,30)/t21-/m0/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : ≥ 30 mg/mL (66.74 mM).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

Iberdomide contains a glutarimide ring that binds in the try-tryptophan pocket of cereblon and an isoindolinone ring that can interact with both cereblon and substrates. Treatment with Iberdomide results in the loss of Ikaros and Aiolos protein levels with EC50s of 1 nM and 0.5 nM .

In Vivo:

Iberdomide (CC-220) is currently in phase 2 clinical trials for the treatment of systematic lupus erythematosus (SLE) and phase 1b/2a clinical trials for relapsed and refractory multiple myeloma (MM).

Products are for research use only. Not for human use.

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