VU0453379


Catalog No. Size PriceQuantity
M14408-2 Contact sales@xcessbio.com for quotation $100

Description

VU0453379 is a highly selective and central nervous system (CNS) penetrant positive allosteric modulator (PAM) of glucagon-like peptide-1R (GLP-1R) with an EC50 of 1.3 μM.

Product information

CAS Number: 1638646-27-1

Molecular Weight: 434.57

Formula: C26H34N4O2

Chemical Name: 2-cyclopentyl-9-methyl-1-oxo-N-{[(2S)-1-(propan-2-yl)pyrrolidin-2-yl]methyl}-1H,2H,9H-pyrido[3,4-b]indole-4-carboxamide

Smiles: CN1C2=C(C(=CN(C3CCCC3)C2=O)C(=O)NC[C@@H]2CCCN2C(C)C)C2C=CC=CC1=2

InChiKey: OEYYOVRNPJSWTO-IBGZPJMESA-N

InChi: InChI=1S/C26H34N4O2/c1-17(2)29-14-8-11-19(29)15-27-25(31)21-16-30(18-9-4-5-10-18)26(32)24-23(21)20-12-6-7-13-22(20)28(24)3/h6-7,12-13,16-19H,4-5,8-11,14-15H2,1-3H3,(H,27,31)/t19-/m0/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

  1. Morris LC, et al. Discovery of (S)-2-cyclopentyl-N-((1-isopropylpyrrolidin2-yl)-9-methyl-1-oxo-2,9-dihydro-1H-pyrrido[3,4-b]indole-4-carboxamide (VU0453379): a novel, CNS penetrant glucagon-like peptide 1 receptor (GLP-1R) positive allosteric modulator (PAM). J Med Chem. 2014 Dec 11;57(23):10192-7.

Products are for research use only. Not for human use.

Payment & Security

PayPal Venmo

Your payment information is processed securely. We do not store credit card details nor have access to your credit card information.

Estimate shipping

You may also like

Recently viewed