Description
Farnesol is a sesquiterpene alcohol that modulates cell-to-cell communication in Candida albicans, and has the activity in inhibiting bacteria.
Product information
CAS Number: 4602-84-0
Molecular Weight: 222.37
Formula: C15H26O
Chemical Name: (2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-ol
Smiles: CC(C)=CCC/C(/C)=C/CC/C(/C)=C/CO
InChiKey: CRDAMVZIKSXKFV-YFVJMOTDSA-N
InChi: InChI=1S/C15H26O/c1-13(2)7-5-8-14(3)9-6-10-15(4)11-12-16/h7,9,11,16H,5-6,8,10,12H2,1-4H3/b14-9+,15-11+
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO : 100 mg/mL (449.70 mM; Need ultrasonic).
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
Farnesol is a sesquiterpene alcohol that modulates cell-to-cell communication in Candida albicans. It is also shown that this molecule presents inhibitory effects against non-albicans Candida species, Paracoccidioides brasiliensis and bacteria. The minimum inhibitory concentrations (MICs) are determined in accordance with the M27-A3 protocol as described and Farnesol is tested at a concentration range of 0.29-150 μM. It is observed that Farnesol presents an inhibitory activity against C. neoformans and C. gattii (MIC range: 0.29-75.0 μM). Although Farnesol does not significantly alter phospholipase activity, a tendency to decrease this activity is observed.
References:
- Cordeiro Rde A, et al. Farnesol inhibits in vitro growth of the Cryptococcus neoformans species complex with no significant changes in virulence-related exoenzymes. Vet Microbiol. 2012 Oct 12;159(3-4):375-80.
Products are for research use only. Not for human use.
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