Propargyl-PEG2-Ms


Catalog No. Size PriceQuantity
M14668-2 Contact sales@xcessbio.com for quotation $100

Description

Propargyl-PEG2-Ms is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.

Product information

CAS Number: 943726-01-0

Molecular Weight: 222.26

Formula: C8H14O5S

Chemical Name: 2-[2-(prop-2-yn-1-yloxy)ethoxy]ethyl methanesulfonate

Smiles: CS(=O)(=O)OCCOCCOCC#C

InChiKey: CNUSDGRUYDRKPO-UHFFFAOYSA-N

InChi: InChI=1S/C8H14O5S/c1-3-4-11-5-6-12-7-8-13-14(2,9)10/h1H,4-8H2,2H3

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

References:

  1. Bai S, et al. Synthesis and structure-activity relationship studies of conformationally flexibletetrahydroisoquinolinyl triazole carboxamide and triazole substituted benzamide analogues as σ2 receptor ligands. J Med Chem. 2014 May 22;57(10):4239-51.

Products are for research use only. Not for human use.

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