Description
(-)-Bicuculline methobromide (l-Bicuculline methobromide) is a potent GABAA receptor antagonist. (-)-Bicuculline methobromide blocks afterhyperpolarizations (AHPs) mediated by Ca2+-activated K+ channels in various types of neurons.
Product information
CAS Number: 73604-30-5
Molecular Weight: 462.29
Formula: C21H20BrNO6
Synonym:
l-Bicuculline methobromide
Chemical Name: (5R)-6,6-dimethyl-5-[(10S)-12-oxo-3,5,11-trioxatricyclo[7.3.0.0²,⁶]dodeca-1,6,8-trien-10-yl]-2H,5H,6H,7H,8H-[1,3]dioxolo[4,5-g]isoquinolin-6-ium bromide
Smiles: [Br-].C[N+]1(C)CCC2C=C3OCOC3=CC=2[C@@H]1[C@H]1OC(=O)C2=C3OCOC3=CC=C21
InChiKey: BWXCECYGGMGBHD-VOMIJIAVSA-M
InChi: InChI=1S/C21H20NO6.BrH/c1-22(2)6-5-11-7-15-16(26-9-25-15)8-13(11)18(22)19-12-3-4-14-20(27-10-24-14)17(12)21(23)28-19;/h3-4,7-8,18-19H,5-6,9-10H2,1-2H3;1H/q+1;/p-1/t18-,19+;/m1./s1
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vivo:
(-)-Bicuculline methobromide (0.6 nmol/rat) attenuates the antiallodynic effect of Neurotropin.
References:
- Seutin V, et al. Recent advances in the pharmacology of quaternary salts of bicuculline. Trends Pharmacol Sci. 1999 Jul;20(7):268-70.
- Okazaki R, et al. The antiallodynic effect of Neurotropin is mediated via activation of descending pain inhibitory systems in rats with spinal nerve ligation. Anesth Analg. 2008 Sep;107(3):1064-9.
Products are for research use only. Not for human use.
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