NSC16168


Catalog No. Size PriceQuantity
M14870-2 2mg solid $220
M14870-10 10mg solid $795

Description

NSC16168 is a specific inhibitor of ERCC1-XPF, with an IC50 value of 0.42 μM. NSC16168 inhibits DNA repair and potentiates CDDP efficacy in cancer.

Product information

CAS Number: 6837-93-0

Molecular Weight: 473.50

Formula: C17H15NO9S3

Chemical Name: 4-amino-5-[(4-methylbenzenesulfonyl)oxy]naphthalene-2,7-disulfonic acid

Smiles: CC1C=CC(=CC=1)S(=O)(=O)OC1C=C(C=C2C=C(C=C(N)C2=1)S(O)(=O)=O)S(O)(=O)=O

InChiKey: ZIQWUYNDHGXLIN-UHFFFAOYSA-N

InChi: InChI=1S/C17H15NO9S3/c1-10-2-4-12(5-3-10)30(25,26)27-16-9-14(29(22,23)24)7-11-6-13(28(19,20)21)8-15(18)17(11)16/h2-9H,18H2,1H3,(H,19,20,21)(H,22,23,24)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 31.25 mg/mL (66.00 mM; Need ultrasonic).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

NSC16168 (0-50 μM) potentiates cisplatin efficacy in cancer cells.

In Vivo:

NSC16168 (20 mg/kg, ip, twice daily) exhibits significant anti-tumor activity and potentiates cisplatin antitumor activity in H460 lung cancer xenografts.

References:

  1. Arora S, et al. Identification of small molecule inhibitors of ERCC1-XPF that inhibit DNA repair and potentiate cisplatin efficacy in cancer cells. Oncotarget. 2016 Nov 15;7(46):75104-75117.

Products are for research use only. Not for human use.

Payment & Security

PayPal Venmo

Your payment information is processed securely. We do not store credit card details nor have access to your credit card information.

Estimate shipping

You may also like

Recently viewed