Description
BIO-013077-01 is a pyrazole TGF-β inhibitor.
Product information
CAS Number: 746667-48-1
Molecular Weight: 287.32
Formula: C17H13N5
Chemical Name: 6-[3-(6-methylpyridin-2-yl)-1H-pyrazol-4-yl]quinoxaline
Smiles: CC1=CC=CC(=N1)C1=NNC=C1C1C=C2N=CC=NC2=CC=1
InChiKey: VXJLYXCHOKEODY-UHFFFAOYSA-N
InChi: InChI=1S/C17H13N5/c1-11-3-2-4-15(21-11)17-13(10-20-22-17)12-5-6-14-16(9-12)19-8-7-18-14/h2-10H,1H3,(H,20,22)
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
A wide range of cellular functions such as cell proliferation, differentiation, adhesion, migration, and apoptosis are regulated by TGF-β superfamily members. The TGF-βs include the three major TGF-β isoforms, TGF-β1, TGF-β2, and TGF-β3 which are expressed in mammals. TGF-β transduces signals through a complex of two related but structurally and functionally distinct serine/threonine kinase receptors, termed type 1 and type II. Deregulation of TGF-β signaling has been also implicated in various human diseases including cancer, pancreatic diseases, and hematological malignancies.
In Vivo:
TGF-β Inhibitor
Products are for research use only. Not for human use.
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