Description
PD-1/PD-L1-IN 5 TFA is a PD-1/PD-L1 protein/protein interaction inhibitor extracted from patent WO2017222976A1, compound Example 1, has an IC50 of ≤100 nM.
Product information
CAS Number: 2170209-52-4
Molecular Weight: 532.49
Formula: C24H19F3N4O5S
Chemical Name: N-[2-cyano-3-(2, 3-dihydro-1, 4-benzodioxin-6-yl)phenyl]-4H, 5H, 6H, 7H-[1, 3]thiazolo[5, 4-c]pyridine-2-carboxamide; trifluoroacetic acid
Smiles: N#CC1C(=CC=CC=1C1=CC2OCCOC=2C=C1)NC(=O)C1=NC2CCNCC=2S1.OC(=O)C(F)(F)F
InChiKey: NXSIYKOVCRSFRA-UHFFFAOYSA-N
InChi: InChI=1S/C22H18N4O3S.C2HF3O2/c23-11-15-14(13-4-5-18-19(10-13)29-9-8-28-18)2-1-3-16(15)25-21(27)22-26-17-6-7-24-12-20(17)30-22;3-2(4,5)1(6)7/h1-5,10,24H,6-9,12H2,(H,25,27);(H,6,7)
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
The compounds modulate PD-1/PD-L1 protein/protein interaction and are useful in the treatment of various diseases including infectious diseases and cancer. The compounds can be used as immunomodulators.
Products are for research use only. Not for human use.
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