PD-1/PD-L1-IN 5 TFA - CAS# 2170209-52-4


Catalog No. Size PriceQuantity
M15424-2 Contact sales@xcessbio.com for quotation $100

Description

PD-1/PD-L1-IN 5 TFA is a PD-1/PD-L1 protein/protein interaction inhibitor extracted from patent WO2017222976A1, compound Example 1, has an IC50 of ≤100 nM.

Product information

CAS Number: 2170209-52-4

Molecular Weight: 532.49

Formula: C24H19F3N4O5S

Chemical Name: N-[2-cyano-3-(2, 3-dihydro-1, 4-benzodioxin-6-yl)phenyl]-4H, 5H, 6H, 7H-[1, 3]thiazolo[5, 4-c]pyridine-2-carboxamide; trifluoroacetic acid

Smiles: N#CC1C(=CC=CC=1C1=CC2OCCOC=2C=C1)NC(=O)C1=NC2CCNCC=2S1.OC(=O)C(F)(F)F

InChiKey: NXSIYKOVCRSFRA-UHFFFAOYSA-N

InChi: InChI=1S/C22H18N4O3S.C2HF3O2/c23-11-15-14(13-4-5-18-19(10-13)29-9-8-28-18)2-1-3-16(15)25-21(27)22-26-17-6-7-24-12-20(17)30-22;3-2(4,5)1(6)7/h1-5,10,24H,6-9,12H2,(H,25,27);(H,6,7)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

The compounds modulate PD-1/PD-L1 protein/protein interaction and are useful in the treatment of various diseases including infectious diseases and cancer. The compounds can be used as immunomodulators.

Products are for research use only. Not for human use.

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