(3S, 5S)-Atorvastatin


Catalog No. Size PriceQuantity
M16149-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

(3S,5S)-Atorvastatin is a inactive enantiomer of Atorvastatin. (3S,5S)-Atorvastatin can activate pregnane X receptor (PXR). Atorvastatin is an orally active HMG-CoA reductase inhibitor, has the ability to effectively decrease blood lipids.

Product information

CAS Number: 501121-34-2

Molecular Weight: 558.64

Formula: C33H35FN2O5

Chemical Name: (3S, 5S)-7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3, 5-dihydroxyheptanoic acid

Smiles: CC(C)C1=C(C(=C(C2C=CC(F)=CC=2)N1CC[C@H](O)C[C@H](O)CC(O)=O)C1C=CC=CC=1)C(=O)NC1C=CC=CC=1

InChiKey: XUKUURHRXDUEBC-SVBPBHIXSA-N

InChi: InChI=1S/C33H35FN2O5/c1-21(2)31-30(33(41)35-25-11-7-4-8-12-25)29(22-9-5-3-6-10-22)32(23-13-15-24(34)16-14-23)36(31)18-17-26(37)19-27(38)20-28(39)40/h3-16,21,26-27,37-38H,17-20H2,1-2H3,(H,35,41)(H,39,40)/t26-,27-/m0/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 125 mg/mL (223.76 mM; Need ultrasonic).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

Atorvastatin and its inactive enantiomer (3S,5S)-Atorvastatin increases CYP2B and CYP3A mRNA content with equal ability. (3S,5S)-Atorvastatin in 100 μM concentrations induces luciferase activity with an EC50 of 12.4 μM. Addition of (3S,5S)-Atorvastatin to the 2-formylphenylboronic acid (FPBA)/l-tryptophanol mixture induces an intensity enhancement of l-tryptophanol florescence.

Products are for research use only. Not for human use.

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