Description
(Rac)-AMG8379 ((Rac)-AMG8380) is a racemate of AMG8379. AMG8379 is a potent, orally active and selective sulfonamide antagonist of NaV1.7, with IC50s of 8.5 and 18.6 nM for hNaV1.7 and mNaV1.7, respectively .
Product information
CAS Number: 1641574-26-6
Molecular Weight: 543.93
Formula: C25H16ClF2N3O5S
Chemical Name: 1-(3'-chloro-2, 5'-difluoro-5-methoxy-[1, 1'-biphenyl]-4-yl)-N-(isoxazol-3-yl)-2-oxo-1, 2-dihydroquinoline-6-sulfonamide
Smiles: COC1=CC(=C(F)C=C1N1C(=O)C=CC2=CC(=CC=C12)S(=O)(=O)NC1C=CON=1)C1C=C(F)C=C(Cl)C=1
InChiKey: HXQNEKJQBGXFAG-UHFFFAOYSA-N
InChi: InChI=1S/C25H16ClF2N3O5S/c1-35-23-12-19(15-8-16(26)11-17(27)9-15)20(28)13-22(23)31-21-4-3-18(10-14(21)2-5-25(31)32)37(33,34)30-24-6-7-36-29-24/h2-13H,1H3,(H,29,30)
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
Products are for research use only. Not for human use.
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