Description
(E/Z)-Sivopixant (Compound I-127) is a potent P2X3 receptor antagonist with an IC50 of 4 nM. (E/Z)-Sivopixant can be used for respiratory diseases research.
Product information
CAS Number: 1640808-39-4
Molecular Weight: 507.93
Formula: C25H22ClN5O5
Chemical Name: (S)-3-(3-(4-chlorobenzyl)-2, 6-dioxo-4-((4-(pyridin-2-yloxy)phenyl)amino)-3, 6-dihydro-1, 3, 5-triazin-1(2H)-yl)-2-methylpropanoic acid
Smiles: C[C@@H](CN1C(=O)N=C(NC2C=CC(=CC=2)OC2=CC=CC=N2)N(CC2C=CC(Cl)=CC=2)C1=O)C(O)=O
InChiKey: SKZQFKBIJUXXCG-INIZCTEOSA-N
InChi: InChI=1S/C25H22ClN5O5/c1-16(22(32)33)14-31-24(34)29-23(30(25(31)35)15-17-5-7-18(26)8-6-17)28-19-9-11-20(12-10-19)36-21-4-2-3-13-27-21/h2-13,16H,14-15H2,1H3,(H,32,33)(H,28,29,34)/t16-/m0/s1
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
ATP receptors are roughly classified into an ion channel type P2X family and a G protein coupled type P2Y family. Seven types of subtypes have been reported in the P2X receptor family, and function as non-selective cation channels by forming homotrimers or heterotrimers with other P2X subtypes. Furthermore, P2X3 that the receptor is expressed in neuroepithelial bodies (NEB) of the lungs, and ATP-induced cough, etc., P2X3 receptors It has been suggested that it is involved in information transmission in the respiratory organs.
Products are for research use only. Not for human use.
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