YZ129


Catalog No. Size PriceQuantity
M16997-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

YZ129 is an inhibitor of the HSP90-calcineurin-NFAT pathway against glioblastoma, directly binding to heat shock protein 90 (HSP90) with an IC50 of 820 nM on NFAT nuclear translocation. YZ129-induced GBM cell-cycle arrest at the G2/M phase promotes apoptosis and inhibited tumor cell proliferation and migration.

Product information

CAS Number: 1643120-60-8

Molecular Weight: 300.31

Formula: C19H12N2O2

Chemical Name: 4-[(isoquinolin-6-yl)amino]-1, 2-dihydronaphthalene-1, 2-dione

Smiles: O=C1C=C(NC2=CC3=CC=NC=C3C=C2)C2=CC=CC=C2C1=O

InChiKey: NYDMVPHEEBVAHT-UHFFFAOYSA-N

InChi: InChI=1S/C19H12N2O2/c22-18-10-17(15-3-1-2-4-16(15)19(18)23)21-14-6-5-13-11-20-8-7-12(13)9-14/h1-11,21H

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 5.6 mg/mL (18.65 mM; ultrasonic and warming and heat to 80°C).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

Products are for research use only. Not for human use.

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