Description
(RS)-MCPG (alpha-MCPG) is a competitive and selective group I/group II metabotropic glutamate receptor (mGluR) antagonist. (RS)-MCPG blocks theta-burst stimulation (TBS)-induced shifts in both juvenile and neonatal rat hippocampal neurons.
Product information
CAS Number: 146669-29-6
Molecular Weight: 209.20
Formula: C10H11NO4
Chemical Name: 4-(1-amino-1-carboxyethyl)benzoic acid
Smiles: CC(N)(C1C=CC(=CC=1)C(O)=O)C(O)=O
InChiKey: DNCAZYRLRMTVSF-UHFFFAOYSA-N
InChi: InChI=1S/C10H11NO4/c1-10(11,9(14)15)7-4-2-6(3-5-7)8(12)13/h2-5H,11H2,1H3,(H,12,13)(H,14,15)
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO : 6 mg/mL (28.68 mM; Need ultrasonic and warming). H2O : < 0.1 mg/mL (ultrasonic;heat to 80°C) (insoluble).
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
MCPG can block group I (mGluR1 and mGluR5) and group II receptors (mGluR2 and mGluR3).
In Vivo:
(RS)-MCPG (alpha-MCPG; 500 μM) blocks the TBS-induced shifts in EGABA in either juvenile or neonatal neurons. Pretreatment with the low dose of (RS)-MCPG (25 nM; i.c.; daily; 5 days) significantly attenuates amphetamine-induced locomotor activity in 10-day-old male and female rats of Sprague-Dawley descent.
Products are for research use only. Not for human use.
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