YU238259


Catalog No. Size PriceQuantity
M19774-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

YU238259 is an inhibitor of homology-dependent DNA repair (HDR), used for cancer research.

Product information

CAS Number: 1943733-16-1

Molecular Weight: 459.95

Formula: C22H22ClN3O4S

Chemical Name: N-[2-(5-chloropyridin-2-yl)ethyl]-4-[(4-methoxybenzenesulfonamido)methyl]benzamide

Smiles: COC1C=CC(=CC=1)S(=O)(=O)NCC1=CC=C(C=C1)C(=O)NCCC1=CC=C(Cl)C=N1

InChiKey: BIHURSOREGLQBB-UHFFFAOYSA-N

InChi: InChI=1S/C22H22ClN3O4S/c1-30-20-8-10-21(11-9-20)31(28,29)26-14-16-2-4-17(5-3-16)22(27)24-13-12-19-7-6-18(23)15-25-19/h2-11,15,26H,12-14H2,1H3,(H,24,27)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 110 mg/mL (239.16 mM; Need ultrasonic).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

YU238259 is an inhibitor of homology-dependent DNA repair, with no effect on PARP activity. YU238259 shows cytotoxicity in BRCA2-deficient cells, with a low LD50 of 8.5 μM. YU238259 (0-5 μM) causes a potent, dose-dependent decrease in HDR efficiency in U2OS DR-GFP or U2OS EJ5-GFP cells, but with no effect on NHEJ frequency. YU238259 (0-10 μM) exhibits synthetic lethality with loss of frequently mutated tumor suppressors, and shows synergism with radiotherapy (IR) and DNA-damaging chemotherapy that is potentiated by BRCA2 loss.

In Vivo:

YU238259 (3 mg/kg, i.p.) inhibits the growth of BRCA2-deficient tumor xenografts in nude mice.

Products are for research use only. Not for human use.

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