(S)-(+)-Dimethindene maleate


Catalog No. Size PriceQuantity
M19984-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

(S)-(+)-Dimethindene maleate, an enantiomer, is a potent M2-selective muscarinic receptor antagonist (pA2 = 7.86/7.74; pKi = 7.78). (S)-(+)-Dimethindene maleate shows lower affinities for the muscarinic M1 (pA2 = 6.83/6.36; pKi = 7.08), the M3 (pA2 = 6.92/6.96; pKi = 6.70) and the M4 receptors (pKi = 7.00), respectively. (S)-(+)-Dimethindene maleate also is a histamine H1 receptor antagonist (pA2 = 7.8).

Product information

CAS Number: 136152-65-3

Molecular Weight: 408.49

Formula: C24H28N2O4

Chemical Name: (2Z)-but-2-enedioic acid; dimethyl(2-{3-[(1S)-1-(pyridin-2-yl)ethyl]-1H-inden-2-yl}ethyl)amine

Smiles: C[C@@H](C1C2=CC=CC=C2CC=1CCN(C)C)C1C=CC=CN=1.OC(=O)/C=C\C(O)=O

InChiKey: SWECWXGUJQLXJF-HFNHQGOYSA-N

InChi: InChI=1S/C20H24N2.C4H4O4/c1-15(19-10-6-7-12-21-19)20-17(11-13-22(2)3)14-16-8-4-5-9-18(16)20;5-3(6)1-2-4(7)8/h4-10,12,15H,11,13-14H2,1-3H3;1-2H,(H,5,6)(H,7,8)/b;2-1-/t15-;/m1./s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

(S)-(+)-Dimethinden is an important regulator in the maintenance of EPS cell developmental potency.

In Vivo:

(S)-(+)-Dimethindene maleate shows affinity profile at muscarinic M1 (NB-OK 1 cells), M2 (rat heart), M3 (rat pancreas) and M4 receptors (rat striatum), with pKis 7.08, 7.78, 6.7 and 7,respectively.

Products are for research use only. Not for human use.

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