VUF10460


Catalog No. Size PriceQuantity
M20427-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

VUF10460 is a non-imidazole histamine H4 receptor agonist; binds to rat H4 receptor with a pKi of 7.46.

Product information

CAS Number: 1028327-66-3

Molecular Weight: 269.34

Formula: C15H19N5

Chemical Name: 4-(4-methylpiperazin-1-yl)-6-phenyl-1,2-dihydropyrimidin-2-imine

Smiles: CN1CCN(CC1)C1C=C(NC(=N)N=1)C1C=CC=CC=1

InChiKey: NIJGWJIOMPHDBP-UHFFFAOYSA-N

InChi: InChI=1S/C15H19N5/c1-19-7-9-20(10-8-19)14-11-13(17-15(16)18-14)12-5-3-2-4-6-12/h2-6,11H,7-10H2,1H3,(H2,16,17,18)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : ≥ 36 mg/mL (133.66 mM).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

UF10460 binds to rat H3 and H4 receptor with pKi values of 5.75, and 7.46, respectively. VUF10460 displays approximately a 50-fold selectivity for the rat H4 receptor over the H3 receptor.

In Vivo:

HCl-induced rat gastric lesions is significantly enhanced by the H4 receptor agonists VUF10460. This effect is not modified by H4 receptor antagonist JNJ7777120.

Products are for research use only. Not for human use.

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