Description
WRG-28 is a selective, extracellularly acting DDR2 allosteric inhibitor with an IC50 of 230 nM. WRG-28 uniquely inhibits receptor-ligand interactions via allosteric modulation of the receptor. WRG-28 inhibits tumor invasion and migration, as well as tumor-supporting roles of the stroma, and inhibits metastatic breast tumor cell colonization in the lungs by targeting DDR2.
Product information
CAS Number: 1913291-02-7
Molecular Weight: 410.44
Formula: C21H18N2O5S
Chemical Name: N-ethyl-4-{[(3-oxo-3H-phenoxazin-7-yl)oxy]methyl}benzene-1-sulfonamide
Smiles: CCNS(=O)(=O)C1=CC=C(COC2=CC3OC4=CC(=O)C=CC4=NC=3C=C2)C=C1
InChiKey: AARVTLIQNGAELZ-UHFFFAOYSA-N
InChi: InChI=1S/C21H18N2O5S/c1-2-22-29(25,26)17-7-3-14(4-8-17)13-27-16-6-10-19-21(12-16)28-20-11-15(24)5-9-18(20)23-19/h3-12,22H,2,13H2,1H3
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO : 15.62 mg/mL (38.06 mM; Need ultrasonic).
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
Products are for research use only. Not for human use.
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