CP-96486


Catalog No. Size PriceQuantity
M20842-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

CP-96486 is a potent and orally active leukotriene D4 (LTD4)/platelet activating factor (PAF) receptor antagonist with Kis of 20 and 24 nM, respectively.

Product information

CAS Number: 139401-45-9

Molecular Weight: 502.99

Formula: C31H23ClN4O

Chemical Name: 7-chloro-2-[(E)-2-{3-[(4-{2-methyl-1H-imidazo[4,5-c]pyridin-1-yl}phenoxy)methyl]phenyl}ethenyl]quinoline

Smiles: CC1=NC2C=NC=CC=2N1C1C=CC(=CC=1)OCC1=CC(/C=C/C2C=CC3=CC=C(Cl)C=C3N=2)=CC=C1

InChiKey: ZKHUZIGQNHJVGZ-WEVVVXLNSA-N

InChi: InChI=1S/C31H23ClN4O/c1-21-34-30-19-33-16-15-31(30)36(21)27-11-13-28(14-12-27)37-20-23-4-2-3-22(17-23)5-9-26-10-7-24-6-8-25(32)18-29(24)35-26/h2-19H,20H2,1H3/b9-5+

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

CP-96486 (CP-96,486) antagonizes 3H-LTD4 binding to guinea pig lung membranes and 3H-PAF binding to rabbit platelets with Ki's of 20 and 24 nM respectively.

In Vivo:

CP-96486 (CP-96,486) inhibits iv LTD4- and iv PAF-induced bronchoconstriction in guinea pigs with ED50's of 0.27 and 0.26 mg/kg p.o. respectively.

Products are for research use only. Not for human use.

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