GW 766994


Catalog No. Size PriceQuantity
M21329-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

GW 766994 (GW 994) is an orally active and specific chemokine receptor-3 (CCR3) antagonist. GW 766994 has the potential for asthma and eosinophilic bronchitis research.

Product information

CAS Number: 408303-43-5

Molecular Weight: 451.35

Formula: C21H24Cl2N4O3

Chemical Name: 4-{[({[(2S)-4-[(3,4-dichlorophenyl)methyl]morpholin-2-yl]methyl}carbamoyl)amino]methyl}benzamide

Smiles: NC(=O)C1C=CC(CNC(=O)NC[C@H]2CN(CC3=CC(Cl)=C(Cl)C=C3)CCO2)=CC=1

InChiKey: GPLUUMAKBFSDIE-KRWDZBQOSA-N

InChi: InChI=1S/C21H24Cl2N4O3/c22-18-6-3-15(9-19(18)23)12-27-7-8-30-17(13-27)11-26-21(29)25-10-14-1-4-16(5-2-14)20(24)28/h1-6,9,17H,7-8,10-13H2,(H2,24,28)(H2,25,26,29)/t17-/m0/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 56 mg/mL (124.07 mM; Need ultrasonic).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

GW 766994 is a specific chemokine receptor-3 (CCR3) antagonist, which has entered clinical trial for asthma and eosinophilic bronchitis. GW 766994 (10 μM) reverses CCL11-induced activation of CDK5, phosphorylations of CDK5, GSK3β, and increased phosphorylation of tau in hippocampal neurons.

Products are for research use only. Not for human use.

Payment & Security

PayPal Venmo

Your payment information is processed securely. We do not store credit card details nor have access to your credit card information.

You may also like

Recently viewed