Description
GW 766994 (GW 994) is an orally active and specific chemokine receptor-3 (CCR3) antagonist. GW 766994 has the potential for asthma and eosinophilic bronchitis research.
Product information
CAS Number: 408303-43-5
Molecular Weight: 451.35
Formula: C21H24Cl2N4O3
Chemical Name: 4-{[({[(2S)-4-[(3,4-dichlorophenyl)methyl]morpholin-2-yl]methyl}carbamoyl)amino]methyl}benzamide
Smiles: NC(=O)C1C=CC(CNC(=O)NC[C@H]2CN(CC3=CC(Cl)=C(Cl)C=C3)CCO2)=CC=1
InChiKey: GPLUUMAKBFSDIE-KRWDZBQOSA-N
InChi: InChI=1S/C21H24Cl2N4O3/c22-18-6-3-15(9-19(18)23)12-27-7-8-30-17(13-27)11-26-21(29)25-10-14-1-4-16(5-2-14)20(24)28/h1-6,9,17H,7-8,10-13H2,(H2,24,28)(H2,25,26,29)/t17-/m0/s1
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO : 56 mg/mL (124.07 mM; Need ultrasonic).
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
GW 766994 is a specific chemokine receptor-3 (CCR3) antagonist, which has entered clinical trial for asthma and eosinophilic bronchitis. GW 766994 (10 μM) reverses CCL11-induced activation of CDK5, phosphorylations of CDK5, GSK3β, and increased phosphorylation of tau in hippocampal neurons.
Products are for research use only. Not for human use.
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