Description
Vatinoxan hydrochloride (MK-467 hydrochloride;L-659066 hydrochloride) is a peripheral α2 adrenergic receptor antagonist.
Product information
CAS Number: 130466-38-5
Molecular Weight: 454.97
Formula: C20H27ClN4O4S
Chemical Name: N-{2-[(2'S,4R)-2-oxo-17'-oxa-7'-azaspiro[imidazolidine-4,4'-tetracyclo[8.7.0.0²,⁷.0¹¹,¹⁶]heptadecane]-1'(10'),11',13',15'-tetraen-3-yl]ethyl}methanesulfonamide hydrochloride
Smiles: Cl.CS(=O)(=O)NCCN1C(=O)NC[C@]21C[C@H]1C3OC4=CC=CC=C4C=3CCN1CC2
InChiKey: UTMOWVIYZQWJHT-VASSOYJASA-N
InChi: InChI=1S/C20H26N4O4S.ClH/c1-29(26,27)22-8-11-24-19(25)21-13-20(24)7-10-23-9-6-15-14-4-2-3-5-17(14)28-18(15)16(23)12-20;/h2-5,16,22H,6-13H2,1H3,(H,21,25);1H/t16-,20+;/m0./s1
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: H2O : ≥ 133 mg/mL (292.33 mM).
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vivo:
Vatinoxan alone increases cardiac index and tissue oxygen delivery and has no deleterious adverse effects. Vatinoxan attenuates or prevents dexmedetomidine’s systemic hemodynamic effects in a dose-dependent manner when given simultaneously i.v. but has no effect on the pulmonary outcome in conscious dogs. A 50:1 dose ratio (Vatinoxan:dexmedetomidine) induces the least alterations in cardiovascular function. Vatinoxan dose-dependently attenuates the bradycardia associated with dexmedetomidine, and shortens the sedative effect without altering its quality. Vatinoxan may be useful in attenuating reductions in heart rate in conscious catsadministered dexmedetomidine.
Products are for research use only. Not for human use.
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