Description
(Rac)-HAMI 3379 is the racemate of HAMI 3379. HAMI 3379 is a potent and selective Cysteinyl leukotriene (CysLT2) receptor antagonist.
Product information
CAS Number: 712313-35-4
Molecular Weight: 595.72
Formula: C34H45NO8
Chemical Name: 3-[(3-carboxycyclohexyl)carbamoyl]-4-(3-{4-[4-(cyclohexyloxy)butoxy]phenyl}propoxy)benzoic acid
Smiles: OC(=O)C1CC(CCC1)NC(=O)C1=CC(=CC=C1OCCCC1C=CC(=CC=1)OCCCCOC1CCCCC1)C(O)=O
InChiKey: HRJWSEPIRZRGCL-UHFFFAOYSA-N
InChi: InChI=1S/C34H45NO8/c36-32(35-27-10-6-9-25(22-27)33(37)38)30-23-26(34(39)40)15-18-31(30)43-21-7-8-24-13-16-29(17-14-24)42-20-5-4-19-41-28-11-2-1-3-12-28/h13-18,23,25,27-28H,1-12,19-22H2,(H,35,36)(H,37,38)(H,39,40)
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO : 100 mg/mL (167.86 mM; Need ultrasonic).
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
In a CysLT2 receptor reporter cell line, HAMI3379 antagonizes leukotriene D4- (LTD4-) and leukotriene C4- (LTC4-) induced intracellular calcium mobilization with IC50 values of 3.8 nM and 4.4 nM respectively.
Products are for research use only. Not for human use.
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