Description
Hexadecyl Methyl Glycerol, also known as AMG-C16 with a hexadecyl chain at the sn-1 position, is a novel inhibitor of protein kinase C with IC50 value of about 80 μM . Protein kinase C is a phospholipid-dependent kinase and the intracellular receptor for phorbol 12-myristate-13-acetate (PMA), a substance that activates both the respiratory burst and protein kinase C. PKC enzymes are activated by signals such as increases in the concentration of diacylglycerol (DAG) or calcium ions (Ca2+) . Hexadecyl Methyl Glycerol is a structural analog of diacylglycerol with a hexadecyl chain at the sn-1 position and a methyl group at the sn-2 position. Hexadecyl Methyl Glycerol inhibited the activation of purified protein kinase C by diacylglycerol in the presence of phosphatidylserine. In neutrophilic granulocytes, Hexadecyl Methyl Glycerol inhibited the respiratory burst induced by PDBu in a dose-dependent way. In neutrophils, Hexadecyl Methyl Glycerol inhibited the phosphorylation of purified 47-kDa protein, an important substrate of protein kinase C .
Product information
CAS Number: 96960-92-8
Molecular Weight: 330.55
Formula: C20H42O3
Chemical Name: 3-(hexadecyloxy)-2-methoxypropan-1-ol
Smiles: COC(CO)COCCCCCCCCCCCCCCCC
InChiKey: XAWCMDFDFNRKGK-UHFFFAOYSA-N
InChi: InChI=1S/C20H42O3/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-23-19-20(18-21)22-2/h20-21H,3-19H2,1-2H3
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
Products are for research use only. Not for human use.
Payment & Security
Your payment information is processed securely. We do not store credit card details nor have access to your credit card information.