VEGFR Tyrosine Kinase Inhibitor II


Catalog No. Size PriceQuantity
M22633-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

VEGFR tyrosine kinase inhibitor II is a pyridinyl-anthranilamide compound that inhibits the kinase activities of VEGFR2 (KDR), VEGFR1 (FLT1), and c-Kit (IC50s = 20, 180, and 240 nM, respectively).1 It displays minimal activity against c-Src and EGFR (IC50s = 7 and 7.3 µM, respectively) and is inactive against Cdk1, c-Met, IGF-1R, and PKA (IC50s > 10 µM).1 VEGFR tyrosine kinase inhibitor II has been investigated for its potential to inhibit tumor induced angiogenesis.

Product information

CAS Number: 269390-69-4

Molecular Weight: 337.80

Formula: C19H16ClN3O

Chemical Name: N-(4-chlorophenyl)-2-{[(pyridin-4-yl)methyl]amino}benzamide

Smiles: O=C(NC1C=CC(Cl)=CC=1)C1=CC=CC=C1NCC1=CC=NC=C1

InChiKey: GGPZCOONYBPZEW-UHFFFAOYSA-N

InChi: InChI=1S/C19H16ClN3O/c20-15-5-7-16(8-6-15)23-19(24)17-3-1-2-4-18(17)22-13-14-9-11-21-12-10-14/h1-12,22H,13H2,(H,23,24)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

Products are for research use only. Not for human use.

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