LDC7559


Catalog No. Size PriceQuantity
M27590-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

LDC7559 is a gasdermin D (GSDMD) inhibitor via blocking neutrophil extracellular trap (NET) in the late stages .

Product information

CAS Number: 2407782-01-6

Molecular Weight: 349.38

Formula: C20H19N3O3

Chemical Name: N-[5-(2-methoxyphenyl)-9-oxa-3,4-diazatricyclo[8.4.0.0³,⁷]tetradeca-1(10),4,6,11,13-pentaen-12-yl]acetamide

Smiles: CC(=O)NC1=CC2OCC3=CC(=NN3CC=2C=C1)C1=CC=CC=C1OC

InChiKey: IFOIINXSFCQLOV-UHFFFAOYSA-N

InChi: InChI=1S/C20H19N3O3/c1-13(24)21-15-8-7-14-11-23-16(12-26-20(14)9-15)10-18(22-23)17-5-3-4-6-19(17)25-2/h3-10H,11-12H2,1-2H3,(H,21,24)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : ≥ 125 mg/mL (357.78 mM).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

LDC7559 (1 and 5 μM) inhibits IL-1β release upon inflammasome activation, and significantly blocks the lethal effect of both human and murine GSDMD NT domains transfected into HEK293T cells. LDC7559 functions directly through blocking the activity of the GSDMD NT domain, rather than interfering with the activation and cleavage process.

Products are for research use only. Not for human use.

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