Description
LDC7559 is a gasdermin D (GSDMD) inhibitor via blocking neutrophil extracellular trap (NET) in the late stages .
Product information
CAS Number: 2407782-01-6
Molecular Weight: 349.38
Formula: C20H19N3O3
Chemical Name: N-[5-(2-methoxyphenyl)-9-oxa-3,4-diazatricyclo[8.4.0.0³,⁷]tetradeca-1(10),4,6,11,13-pentaen-12-yl]acetamide
Smiles: CC(=O)NC1=CC2OCC3=CC(=NN3CC=2C=C1)C1=CC=CC=C1OC
InChiKey: IFOIINXSFCQLOV-UHFFFAOYSA-N
InChi: InChI=1S/C20H19N3O3/c1-13(24)21-15-8-7-14-11-23-16(12-26-20(14)9-15)10-18(22-23)17-5-3-4-6-19(17)25-2/h3-10H,11-12H2,1-2H3,(H,21,24)
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO : ≥ 125 mg/mL (357.78 mM).
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
LDC7559 (1 and 5 μM) inhibits IL-1β release upon inflammasome activation, and significantly blocks the lethal effect of both human and murine GSDMD NT domains transfected into HEK293T cells. LDC7559 functions directly through blocking the activity of the GSDMD NT domain, rather than interfering with the activation and cleavage process.
Products are for research use only. Not for human use.
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