MB710


Catalog No. Size PriceQuantity
M28886-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

MB710, an aminobenzothiazole derivative, is a stabilizer of oncogenic p53 mutation Y220C. MB710 binds tightly to the Y220C pocket and stabilizes p53-Y220C, with a Kd of 4.1 μM. MB710 shows anticancer activity in p53-Y220C cell lines.

Product information

CAS Number: 2230044-57-0

Molecular Weight: 457.29

Formula: C16H16IN3O3S

Chemical Name: 2-(diethylamino)-5-hydroxy-6-iodo-7-(1H-pyrrol-1-yl)-1,3-benzothiazole-4-carboxylic acid

Smiles: CCN(CC)C1=NC2=C(C(O)=O)C(O)=C(I)C(=C2S1)N1C=CC=C1

InChiKey: SEBJATZOIHUGAU-UHFFFAOYSA-N

InChi: InChI=1S/C16H16IN3O3S/c1-3-19(4-2)16-18-11-9(15(22)23)13(21)10(17)12(14(11)24-16)20-7-5-6-8-20/h5-8,21H,3-4H2,1-2H3,(H,22,23)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

MB710 (0-200 μM; 72 hours) shows relatively low toxicity against all cell lines tested at concentrations up to 60 μM, while showing initial selective viability reduction at higher concentrations. MB710 (72 hours) treats cancer cell lines NUGC3, NUGC4, WI38 and SW1088, with IC50s of 90, 120, >120, >120 μM, respectively. MB710 (0-120 μM; 72 hours; HUH-7 cells) shows stronger cytotoxic effects in presence of p53-Y220C.

Products are for research use only. Not for human use.

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