Description
Carbazeran (citrate), a potent phosphodiesterase inhibitor, is aldehyde oxidase substrate. Carbazeran (citrate) can be used for the research of metabolic disease.
Product information
CAS Number: 153473-94-0
Molecular Weight: 552.53
Formula: C24H32N4O11
Chemical Name: 1-(6,7-dimethoxyphthalazin-1-yl)piperidin-4-yl N-ethylcarbamate; 2-hydroxypropane-1,2,3-tricarboxylic acid
Smiles: CCNC(=O)OC1CCN(CC1)C1=NN=CC2=CC(OC)=C(C=C21)OC.OC(=O)C(O)(CC(O)=O)CC(O)=O
InChiKey: QKMRPDVEKBYWPF-UHFFFAOYSA-N
InChi: InChI=1S/C18H24N4O4.C6H8O7/c1-4-19-18(23)26-13-5-7-22(8-6-13)17-14-10-16(25-3)15(24-2)9-12(14)11-20-21-17;7-3(8)1-6(13,5(11)12)2-4(9)10/h9-11,13H,4-8H2,1-3H3,(H,19,23);13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vivo:
Carbazeran (10 mg/kg; p.o.) (citrate) of the unmetabolized in samples from humanized-liver mice, the mean plasma concentrations are lower than in those from control mice for 0.5~4 hours after oral administration. Oral administration of carbazeran (citrate) to guinea pigs has reportedly resulted in large kinetic deuterium isotope effects on the AUC and Cmax, without a change of systemic half-life.
Products are for research use only. Not for human use.
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