Zenarestat


Catalog No. Size PriceQuantity
M30110-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

Zenarestat is a potent and orally active aldose reductase inhibitor. Zenarestat improves diabetic peripheral neuropathy in Zucker diabetic fatty rats.

Product information

CAS Number: 112733-06-9

Molecular Weight: 441.64

Formula: C17H11BrClFN2O4

Chemical Name: 2-{3-[(4-bromo-2-fluorophenyl)methyl]-7-chloro-2,4-dioxo-1,2,3,4-tetrahydroquinazolin-1-yl}acetic acid

Smiles: OC(=O)CN1C2=CC(Cl)=CC=C2C(=O)N(CC2=CC=C(Br)C=C2F)C1=O

InChiKey: SXONDGSPUVNZLO-UHFFFAOYSA-N

InChi: InChI=1S/C17H11BrClFN2O4/c18-10-2-1-9(13(20)5-10)7-22-16(25)12-4-3-11(19)6-14(12)21(17(22)26)8-15(23)24/h1-6H,7-8H2,(H,23,24)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vivo:

Zenarestat (3.2, 32 mg/kg; p.o.; daily for 8 weeks) inhibits nerve sorbitol accumulation in a dose-dependent manner.

Products are for research use only. Not for human use.

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