Description
Azido-PEG8-PFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
Product information
CAS Number: 2055014-62-3
Molecular Weight: 633.56
Formula: C25H36F5N3O10
Chemical Name: 2,3,4,5,6-pentafluorophenyl 1-azido-3,6,9,12,15,18,21,24-octaoxaheptacosan-27-oate
Smiles: [N-]=[N+]=NCCOCCOCCOCCOCCOCCOCCOCCOCCC(=O)OC1C(F)=C(F)C(F)=C(F)C=1F
InChiKey: FLLXHBTXSPGUHL-UHFFFAOYSA-N
InChi: InChI=1S/C25H36F5N3O10/c26-20-21(27)23(29)25(24(30)22(20)28)43-19(34)1-3-35-5-7-37-9-11-39-13-15-41-17-18-42-16-14-40-12-10-38-8-6-36-4-2-32-33-31/h1-18H2
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO : 100 mg/mL (157.84 mM; Need ultrasonic).
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
Products are for research use only. Not for human use.
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