α-Lipoic acid-NHS


Catalog No. Size PriceQuantity
M32319-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

α-Lipoic acid-NHS is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs.

Product information

CAS Number: 40846-94-4

Molecular Weight: 303.40

Formula: C12H17NO4S2

Chemical Name: 2,5-dioxopyrrolidin-1-yl 5-(1,2-dithiolan-3-yl)pentanoate

Smiles: O=C(CCCCC1CCSS1)ON1C(=O)CCC1=O

InChiKey: WBCUIGFYTHUQHZ-UHFFFAOYSA-N

InChi: InChI=1S/C12H17NO4S2/c14-10-5-6-11(15)13(10)17-12(16)4-2-1-3-9-7-8-18-19-9/h9H,1-8H2

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

Products are for research use only. Not for human use.

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