Description
2-(Azido-PEG3-amido)-1,3-bis(NHS ester) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
Product information
CAS Number: 2320560-36-7
Molecular Weight: 658.61
Formula: C26H38N6O14
Chemical Name: 2,5-dioxopyrrolidin-1-yl 3-[2-(3-{2-[2-(2-azidoethoxy)ethoxy]ethoxy}propanamido)-3-{3-[(2,5-dioxopyrrolidin-1-yl)oxy]-3-oxopropoxy}propoxy]propanoate
Smiles: [N-]=[N+]=NCCOCCOCCOCCC(=O)NC(COCCC(=O)ON1C(=O)CCC1=O)COCCC(=O)ON1C(=O)CCC1=O
InChiKey: IKNSPJWCHQONRB-UHFFFAOYSA-N
InChi: InChI=1S/C26H38N6O14/c27-30-28-8-12-41-14-16-42-15-13-40-9-5-20(33)29-19(17-43-10-6-25(38)45-31-21(34)1-2-22(31)35)18-44-11-7-26(39)46-32-23(36)3-4-24(32)37/h19H,1-18H2,(H,29,33)
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
Products are for research use only. Not for human use.
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